Assay Detail
Functional
CHEMBL779981
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Effective concentration in rat in the absence of Magnesium
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
A study of the relationship between biological activity and prolyl amide isomer geometry in oxytocin using 5-tert-butylproline to augment the Cys(6)-Pro(7) amide cis-isomer population.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.65 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | 4.0 | 1 | 9.22 |
| CHEMBL2372252 | — | — | 1 | 7.50 |
| CHEMBL2372251 | — | — | 1 | 7.40 |
| CHEMBL2372253 | — | — | 1 | 7.30 |
| CHEMBL429161 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395429 | OXYTOCIN | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2372252 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2372251 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2372253 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL429161 | — | EC50 | = | 150.0 | nM | 6.82 |