Assay Detail
Functional
CHEMBL780006
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required for its norepinephrine reuptake inhibitory activity in synaptosomal rat hyphalamic preparations
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological characterization of ABT-200: a putative novel antidepressant combining potent -2 antagonism with moderate NE uptake inhibition
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.04 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 6.98 |
| CHEMBL285367 | — | — | 1 | 6.20 |
| CHEMBL27926 | NAPITANE | 2.0 | 3 | 6.08 |
| CHEMBL433033 | — | — | 1 | 5.84 |
| CHEMBL25014 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL285367 | — | IC50 | = | 636.0 | nM | 6.20 |
| CHEMBL27926 | NAPITANE | IC50 | = | 841.0 | nM | 6.08 |
| CHEMBL27926 | NAPITANE | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL433033 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL25014 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL27926 | NAPITANE | IC50 | = | 3110.0 | nM | 5.51 |