Assay Detail
Functional
CHEMBL780256
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In vitro inhibition of thromboxane A2 production in rat platelet-rich plasma.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Thromboxane A2 synthetase inhibitors. 2. Syntheses and activities of tetrahydronaphthalene and indan derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.78 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26694 | — | — | 1 | 6.85 |
| CHEMBL27829 | — | — | 1 | 6.82 |
| CHEMBL26756 | — | — | 1 | 6.66 |
| CHEMBL26820 | (E)-ISBOGREL | — | 1 | 6.60 |
| CHEMBL26706 | — | — | 1 | 6.43 |
| CHEMBL285364 | — | — | 1 | 6.40 |
| CHEMBL544450 | — | — | 1 | 6.07 |
| CHEMBL539495 | — | — | 1 | 5.96 |
| CHEMBL554569 | — | — | 1 | 5.85 |
| CHEMBL27633 | — | — | 1 | 5.82 |
| CHEMBL28343 | — | — | 1 | 5.72 |
| CHEMBL286517 | — | — | 1 | 5.42 |
| CHEMBL11662 | OZAGREL | 4.0 | 1 | 5.35 |
| CHEMBL543038 | — | — | 1 | 5.27 |
| CHEMBL540770 | — | — | 1 | 5.25 |
| CHEMBL544688 | — | — | 1 | 5.18 |
| CHEMBL554555 | — | — | 1 | 5.14 |
| CHEMBL267473 | DAZOXIBEN | 2.0 | 1 | 4.96 |
| CHEMBL283656 | DAZMEGREL | 2.0 | 1 | 4.92 |
| CHEMBL26784 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26694 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL27829 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL26756 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL26820 | (E)-ISBOGREL | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL26706 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL285364 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL544450 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL539495 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL554569 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL27633 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL28343 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL286517 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL11662 | OZAGREL | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL543038 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL540770 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL544688 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL554555 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL267473 | DAZOXIBEN | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL283656 | DAZMEGREL | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL26784 | — | IC50 | = | 14000.0 | nM | 4.85 |