Assay Detail
Functional
CHEMBL780257
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In vitro inhibition of veratridine induced LDH release in rat embryos
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.01 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30008 | FLUNARIZINE | 2.0 | 1 | 5.70 |
| CHEMBL329245 | — | — | 1 | 5.36 |
| CHEMBL282833 | — | — | 1 | 5.30 |
| CHEMBL92018 | — | — | 1 | 5.22 |
| CHEMBL330049 | — | — | 1 | 4.92 |
| CHEMBL91288 | — | — | 1 | 4.52 |
| CHEMBL94137 | — | — | 1 | 4.52 |
| CHEMBL93065 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30008 | FLUNARIZINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL329245 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL282833 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL92018 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL330049 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL91288 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL94137 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL93065 | — | IC50 | = | 30000.0 | nM | 4.52 |