Assay Detail
Functional
CHEMBL780344
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for relative potency as NMDA antagonist by determining its ability to inhibit depolarizations induced by 40 uM NMDA in a cortical slice preparation.
10
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Unusual stereochemical preferences of decahydroisoquinoline-3-cargoxylic acid competitive NMDA antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.64 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65631 | — | — | 4 | 6.82 |
| CHEMBL303126 | — | — | 6 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65631 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL65631 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL303126 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL303126 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL65631 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL303126 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL303126 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL303126 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL65631 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL303126 | — | IC50 | > | 100000.0 | nM | - |