Assay Detail
Functional
CHEMBL780354
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for vasorelaxant activity on the basis of ability to relax endothelium-denuded rat aortic strips toned with 20 mM KCl
11
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel potassium-channel openers: preparation and pharmacological evaluation of racemic and optically active N-(6-amino-3-pyridyl)-N'-bicycloalkyl-N"-cyanoguanidine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.73 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL543813 | — | — | 2 | 7.15 |
| CHEMBL291768 | — | — | 1 | 7.05 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.96 |
| CHEMBL62216 | — | — | 1 | 6.93 |
| CHEMBL543576 | — | — | 1 | 6.65 |
| CHEMBL60202 | — | — | 2 | 6.57 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 6.42 |
| CHEMBL542385 | — | — | 1 | 6.41 |
| CHEMBL1202785 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL543813 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL543813 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL291768 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL49035 | CROMAKALIM | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL62216 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL543576 | — | IC50 | = | 223.0 | nM | 6.65 |
| CHEMBL60202 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL60202 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL542385 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL1202785 | — | IC50 | = | 593.0 | nM | 6.23 |