Assay Detail
Functional
CHEMBL780513
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Evaluated for inhibition of norepinephrine, biogenic amine reuptake in synaptosomal rat brain preparations
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological characterization of A-80426: A putative novel antidepressant combining -2 antagonism with 5-HT uptake inhibition
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.17 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 6.80 |
| CHEMBL75342 | — | — | 1 | 6.32 |
| CHEMBL268258 | — | — | 1 | 6.06 |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | 5.48 |
| CHEMBL10347 | RAUWOLSCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490 | PAROXETINE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL75342 | — | IC50 | = | 476.0 | nM | 6.32 |
| CHEMBL268258 | — | IC50 | = | 865.0 | nM | 6.06 |
| CHEMBL41 | FLUOXETINE | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL10347 | RAUWOLSCINE | IC50 | > | 10000.0 | nM | - |