Assay Detail
Functional
CHEMBL780695
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Adenylase cyclase activity in rat striatal membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dopaminergic activity of substituted 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553503 | — | — | 1 | 8.00 |
| CHEMBL553147 | — | — | 1 | 7.35 |
| CHEMBL542152 | — | — | 1 | 6.22 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553503 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL553147 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL542152 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL59 | DOPAMINE | EC50 | = | 3500.0 | nM | 5.46 |