Assay Detail
Functional
CHEMBL781143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration giving 50% inhibition of stimulated [3H](+)-MK-801 binding in rat cortical membranes incubated with 10 uM glycine
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.64 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91115 | — | — | 1 | 4.96 |
| CHEMBL328272 | — | — | 1 | 4.90 |
| CHEMBL90242 | — | — | 1 | 4.54 |
| CHEMBL267276 | TQX-173 | — | 1 | 4.17 |
| CHEMBL90722 | — | — | 1 | - |
| CHEMBL328935 | — | — | 1 | - |
| CHEMBL93076 | — | — | 1 | - |
| CHEMBL222519 | NBQX | — | 1 | - |
| CHEMBL327894 | — | — | 1 | - |
| CHEMBL50267 | — | — | 1 | - |
| CHEMBL91677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91115 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL328272 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL90242 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL267276 | TQX-173 | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL90722 | — | IC50 | - | nM | - | |
| CHEMBL328935 | — | IC50 | - | nM | - | |
| CHEMBL93076 | — | IC50 | - | nM | - | |
| CHEMBL222519 | NBQX | IC50 | - | nM | - | |
| CHEMBL327894 | — | IC50 | - | nM | - | |
| CHEMBL50267 | — | IC50 | - | nM | - | |
| CHEMBL91677 | — | IC50 | - | nM | - |