Assay Detail
Functional
CHEMBL781145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of compound that inhibits by 50% depolarizations induced by 10 uM AMPA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.80 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 6.92 |
| CHEMBL293206 | — | — | 1 | 6.30 |
| CHEMBL121771 | — | — | 1 | 6.16 |
| CHEMBL122054 | — | — | 1 | 5.82 |
| CHEMBL122313 | — | — | 1 | 5.80 |
| CHEMBL333463 | — | — | 1 | 5.75 |
| CHEMBL122082 | — | — | 1 | 4.85 |
| CHEMBL125484 | — | — | 1 | 4.78 |
| CHEMBL121886 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL293206 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL121771 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL122054 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL122313 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL333463 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL122082 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL125484 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL121886 | — | IC50 | > | 30000.0 | nM | - |