Assay Detail
Functional
CHEMBL781264
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In vitro inhibition of Thromboxane B2 production in A-23,187-Induced Rat Whole Blood
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.93 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555463 | — | — | 1 | 6.08 |
| CHEMBL118944 | — | — | 1 | 5.96 |
| CHEMBL118462 | — | — | 1 | 5.75 |
| CHEMBL119841 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555463 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL118944 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL118462 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL119841 | — | IC50 | > | 10000.0 | nM | - |