Assay Detail
Functional
CHEMBL781528
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Tested for effective concentration required to relax contraction induced by 30 mM KCl in rat aorta
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antihypertensive activity of KC-399, a benzopyran K+ channel opener with long duration of action and less tachycardia
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.17 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291410 | — | — | 1 | 9.52 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291410 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL49035 | CROMAKALIM | EC50 | = | 150.0 | nM | 6.82 |