Assay Detail
Functional
CHEMBL781693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of the accumulation of [3H]-NE into rat brain synaptosomes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Octoclothepin enantiomers. A reinvestigation of their biochemical and pharmacological activity in relation to a new receptor-interaction model for dopamine D-2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.15 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 9.27 |
| CHEMBL303313 | — | — | 1 | 9.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64249 | CLOROTEPINE | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL303313 | — | IC50 | = | 0.96 | nM | 9.02 |