Assay Detail
Functional
CHEMBL781894
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro stimulation of norepinephrine release from hippocampal nerve endings.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure--activity studies for alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid receptors: acidic hydroxyphenylalanines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.89 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 5.43 |
| CHEMBL276815 | (S)-AMPA | — | 1 | 5.17 |
| CHEMBL366588 | — | — | 1 | 4.82 |
| CHEMBL108147 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL276815 | (S)-AMPA | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL366588 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL108147 | — | EC50 | = | 74000.0 | nM | 4.13 |