Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL782135

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity against graft vs host disease in rat.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Selective inhibitors of protein kinase C in a model of graft-vs-host disease
Demers JP, Hageman WE, Johnson SG, Klaubert DH, Look RA, Moore JB
Bioorg Med Chem Lett (1994) 4 : 2451 -2456
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.31 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL79682 1 5.80
CHEMBL80111 1 5.60
CHEMBL311192 1 5.58
CHEMBL80658 1 5.54
CHEMBL80059 1 5.52
CHEMBL79836 1 5.52
CHEMBL79798 1 5.47
CHEMBL80058 1 5.44
CHEMBL309772 1 5.43
CHEMBL82547 1 5.38
CHEMBL78466 1 5.38
CHEMBL309386 1 5.36
CHEMBL431593 1 5.35
CHEMBL83332 1 5.32
CHEMBL311475 1 5.24
CHEMBL431004 1 5.24
CHEMBL313402 1 5.21
CHEMBL311068 1 5.15
CHEMBL309437 1 5.10
CHEMBL81130 1 4.96
CHEMBL314696 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL79682 IC50 = 1600.0 nM 5.80
CHEMBL80111 IC50 = 2500.0 nM 5.60
CHEMBL311192 IC50 = 2600.0 nM 5.58
CHEMBL80658 IC50 = 2900.0 nM 5.54
CHEMBL80059 IC50 = 3000.0 nM 5.52
CHEMBL79836 IC50 = 3000.0 nM 5.52
CHEMBL79798 IC50 = 3400.0 nM 5.47
CHEMBL80058 IC50 = 3600.0 nM 5.44
CHEMBL309772 IC50 = 3700.0 nM 5.43
CHEMBL82547 IC50 = 4200.0 nM 5.38
CHEMBL78466 IC50 = 4200.0 nM 5.38
CHEMBL309386 IC50 = 4400.0 nM 5.36
CHEMBL431593 IC50 = 4500.0 nM 5.35
CHEMBL83332 IC50 = 4800.0 nM 5.32
CHEMBL311475 IC50 = 5700.0 nM 5.24
CHEMBL431004 IC50 = 5800.0 nM 5.24
CHEMBL313402 IC50 = 6200.0 nM 5.21
CHEMBL311068 IC50 = 7100.0 nM 5.15
CHEMBL309437 IC50 = 7900.0 nM 5.10
CHEMBL81130 IC50 = 11000.0 nM 4.96
CHEMBL314696 IC50 = 100000.0 nM 4.00