Assay Detail
Functional
CHEMBL782316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the concentration dependent negative ionotropic effect in rat right myocardial ventricular strips
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Cardiac ventricle |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies on Ca2+ channel antagonists. 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2- isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.55 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51149 | GALLOPAMIL | 2.0 | 1 | 5.71 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 5.60 |
| CHEMBL51474 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51149 | GALLOPAMIL | EC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL6966 | VERAPAMIL | EC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL51474 | — | EC50 | = | 4560.0 | nM | 5.34 |