Assay Detail
Functional
CHEMBL782362
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration required for relaxation of rat aortic rings
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of enantiopure thionitrites: the solid-phase synthesis and nitrosation of D-glutathione as a molecular probe.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.25 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300676 | — | — | 1 | 8.70 |
| CHEMBL348409 | — | — | 1 | 8.68 |
| CHEMBL63507 | S-NITROSOGLUTATHIONE | — | 1 | 6.97 |
| CHEMBL156747 | — | — | 1 | 6.54 |
| CHEMBL347940 | — | — | 1 | 6.32 |
| CHEMBL73188 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300676 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL348409 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL63507 | S-NITROSOGLUTATHIONE | EC50 | = | 107.5 | nM | 6.97 |
| CHEMBL156747 | — | EC50 | = | 289.9 | nM | 6.54 |
| CHEMBL347940 | — | EC50 | = | 475.5 | nM | 6.32 |
| CHEMBL73188 | — | EC50 | = | 492.1 | nM | 6.31 |