Assay Detail
Functional
CHEMBL782364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration for stimulation of [3H]diazepam binding to rat cortical membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
()-2-amino-2-thiazoline-4-ethanoic acid; a novel, specific GABAA receptor agonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.49 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39071 | ISOGUVACINE | — | 1 | 5.51 |
| CHEMBL79325 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39071 | ISOGUVACINE | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL79325 | — | EC50 | = | 3400.0 | nM | 5.47 |