Assay Detail
Functional
CHEMBL782597
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ACTH-stimulated aldosterone production in rat adrenal tissue
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Adrenal tissue |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cytochrome P450 11B1, mitochondrial (CHEMBL4970) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468419 | FADROZOLE HYDROCHLORIDE | -1.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468419 | FADROZOLE HYDROCHLORIDE | IC50 | = | 1000.0 | nM | 6.00 |