Assay Detail
Functional
CHEMBL782599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Adenylyl cyclase activity in rat cortical membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.77 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 7.92 |
| CHEMBL3143982 | — | — | 1 | 7.19 |
| CHEMBL3143983 | — | — | 1 | 6.85 |
| CHEMBL3143985 | — | — | 1 | 6.45 |
| CHEMBL3143984 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3143982 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3143983 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3143985 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL3143984 | — | IC50 | = | 3440.0 | nM | 5.46 |