Assay Detail
Functional
CHEMBL782603
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Inhibition of ET-1 stimulated inositol phosphate accumulation in rat fibroblast
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.08 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289687 | — | — | 1 | 5.85 |
| CHEMBL432091 | — | — | 1 | 4.30 |
| CHEMBL2370073 | — | — | 1 | - |
| CHEMBL2370061 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289687 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL432091 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2370073 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2370061 | — | IC50 | > | 100000.0 | nM | - |