Assay Detail
Functional
CHEMBL782610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI (phospho inositol) response in rat hippocampus by the selective antagonist AF-DX 116 in the presence of 50 uM concentration of the compound
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, biochemical activity and behavioral effects of a series of 1,4,5,6-tetrahydropyrimidines as novel ligands for M1 receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.34 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20835 | ACECLIDINE | 3.0 | 1 | 6.55 |
| CHEMBL538467 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20835 | ACECLIDINE | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL538467 | — | IC50 | = | 750.0 | nM | 6.12 |