Assay Detail
Functional
CHEMBL782614
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]- DA (Dopamine) uptake in rat striatal synaptosomes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.11 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | 3.0 | 1 | 8.18 |
| CHEMBL440191 | — | — | 1 | 8.18 |
| CHEMBL160812 | — | — | 1 | 7.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281594 | VANOXERINE | IC50 | = | 6.63 | nM | 8.18 |
| CHEMBL440191 | — | IC50 | = | 6.68 | nM | 8.18 |
| CHEMBL160812 | — | IC50 | = | 10.4 | nM | 7.98 |