Assay Detail
Functional
CHEMBL782642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the response (stimulation of phosphoinositol metabolism in rat hippocampus) to 10 uM of compound by pirenzepine
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.17 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277014 | — | — | 1 | 7.42 |
| CHEMBL20835 | ACECLIDINE | 3.0 | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277014 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL20835 | ACECLIDINE | IC50 | = | 120.0 | nM | 6.92 |