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Assay Detail

CHEMBL782755

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity evaluated against rat Con A embryonic cortical neurons in cellular assay
ChEMBL ↗
71
Total Activities
71
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376) ↗
Type ORGANISM
Organism Rattus norvegicus

Publication

Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.
Linton SD, Aja T, Allegrini PR, Deckwerth TL, Diaz JL, Hengerer B, Herrmann J, Jahangiri KG, Kallen J, Karanewsky DS, Meduna SP, Nalley K, Robinson ED, Roggo S, Rovelli G, Sauter A, Sayers RO, Schmitz A, Smidt R, Ternansky RJ, Tomaselli KJ, Ullman BR, Wiessner C, Wu JC.
Bioorg Med Chem Lett (2004) 14 : 2685 -2691
PubMed 15109679 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 71 5.66 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL430839 — — 1 6.52
CHEMBL92848 — — 1 6.52
CHEMBL91423 — — 1 6.46
CHEMBL327821 — — 1 6.40
CHEMBL90914 — — 1 6.35
CHEMBL330294 — — 1 6.30
CHEMBL91307 — — 1 6.30
CHEMBL91032 — — 1 6.26
CHEMBL88540 — — 1 6.26
CHEMBL91281 — — 1 6.19
CHEMBL90185 — — 1 6.19
CHEMBL316289 — — 1 6.18
CHEMBL91406 — — 1 6.16
CHEMBL313158 — — 1 6.12
CHEMBL330110 — — 1 6.10
CHEMBL88719 — — 1 6.07
CHEMBL90516 — — 1 6.01
CHEMBL94069 — — 1 6.00
CHEMBL315868 — — 1 6.00
CHEMBL91303 — — 1 6.00
CHEMBL314096 — — 1 6.00
CHEMBL327458 — — 1 5.96
CHEMBL88517 — — 1 5.82
CHEMBL327207 — — 1 5.82
CHEMBL315954 — — 1 5.82
CHEMBL88795 — — 1 5.70
CHEMBL91305 — — 1 5.70
CHEMBL314733 — — 1 5.70
CHEMBL328066 — — 1 5.70
CHEMBL91181 — — 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL430839 — IC50 = 300.0 nM 6.52
CHEMBL92848 — IC50 = 300.0 nM 6.52
CHEMBL91423 — IC50 = 350.0 nM 6.46
CHEMBL327821 — IC50 = 400.0 nM 6.40
CHEMBL90914 — IC50 = 450.0 nM 6.35
CHEMBL330294 — IC50 = 500.0 nM 6.30
CHEMBL91307 — IC50 = 500.0 nM 6.30
CHEMBL91032 — IC50 = 550.0 nM 6.26
CHEMBL88540 — IC50 = 550.0 nM 6.26
CHEMBL91281 — IC50 = 650.0 nM 6.19
CHEMBL90185 — IC50 = 650.0 nM 6.19
CHEMBL316289 — IC50 = 660.0 nM 6.18
CHEMBL91406 — IC50 = 700.0 nM 6.16
CHEMBL313158 — IC50 = 750.0 nM 6.12
CHEMBL330110 — IC50 = 800.0 nM 6.10
CHEMBL88719 — IC50 = 850.0 nM 6.07
CHEMBL90516 — IC50 = 970.0 nM 6.01
CHEMBL94069 — IC50 = 1000.0 nM 6.00
CHEMBL315868 — IC50 = 1000.0 nM 6.00
CHEMBL91303 — IC50 = 1000.0 nM 6.00
CHEMBL314096 — IC50 = 1000.0 nM 6.00
CHEMBL327458 — IC50 = 1100.0 nM 5.96
CHEMBL88517 — IC50 = 1500.0 nM 5.82
CHEMBL327207 — IC50 = 1500.0 nM 5.82
CHEMBL315954 — IC50 = 1500.0 nM 5.82
CHEMBL88795 — IC50 = 2000.0 nM 5.70
CHEMBL316102 — IC50 = 2000.0 nM 5.70
CHEMBL88786 — IC50 = 2000.0 nM 5.70
CHEMBL90293 — IC50 = 2000.0 nM 5.70
CHEMBL328066 — IC50 = 2000.0 nM 5.70
CHEMBL314733 — IC50 = 2000.0 nM 5.70
CHEMBL91305 — IC50 = 2000.0 nM 5.70
CHEMBL91181 — IC50 = 2000.0 nM 5.70
CHEMBL88358 — IC50 = 2100.0 nM 5.68
CHEMBL93177 — IC50 = 2300.0 nM 5.64
CHEMBL330534 — IC50 = 2400.0 nM 5.62
CHEMBL90589 — IC50 = 2500.0 nM 5.60
CHEMBL327464 — IC50 = 2500.0 nM 5.60
CHEMBL313390 — IC50 = 2500.0 nM 5.60
CHEMBL91442 — IC50 = 2500.0 nM 5.60
CHEMBL414216 — IC50 = 2580.0 nM 5.59
CHEMBL329787 — IC50 = 2700.0 nM 5.57
CHEMBL90268 — IC50 = 2700.0 nM 5.57
CHEMBL91825 — IC50 = 2900.0 nM 5.54
CHEMBL88728 — IC50 = 2900.0 nM 5.54
CHEMBL329442 — IC50 = 3000.0 nM 5.52
CHEMBL92317 — IC50 = 3280.0 nM 5.48
CHEMBL316450 — IC50 = 3500.0 nM 5.46
CHEMBL327683 — IC50 = 3500.0 nM 5.46
CHEMBL327211 — IC50 = 3500.0 nM 5.46