Assay Detail
Functional
CHEMBL782756
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Inhibitory concentration against 5-HT in conscious spontaneously hypersensitive rats (SHR)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.50 | 9.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71492 | — | — | 1 | 9.44 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 7.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71492 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL51 | KETANSERIN | IC50 | = | 27.8 | nM | 7.56 |