Assay Detail
Functional
CHEMBL782787
Review assay metadata, readout intent, target linkage, and publication context from the same page.
tested for their ability to inhibit the after- hyperpolarization in cultured rat sympathetic neurons (omitting the comparison with dequalinium)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Sympathetic neuron |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.57 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420873 | — | — | 1 | 8.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420873 | — | IC50 | = | 2.7 | nM | 8.57 |