Assay Detail
Functional
CHEMBL782812
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Inhibitory activity against N-methyl-D-aspartate (NMDA)-induced cyclic GMP accumulation in rat cerebellar slices
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nitroaromatic amino acids as inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.28 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 6.70 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 5.52 |
| CHEMBL88166 | — | — | 1 | 4.48 |
| CHEMBL88177 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227744 | NITROARGININE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL256147 | TILARGININE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL88166 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL88177 | — | IC50 | = | 37000.0 | nM | 4.43 |