Assay Detail
Functional
CHEMBL782816
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Inhibitory activity against peroxidation of rat cardiac membrane liposomes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
4-[5-(2,3-dihydroxyphenyl)pentyloxy]-2-hydroxy-3-propylbenzoic acid (Ro 24-0553): an orally active 5-lipoxygenase inhibitor with antiinflammatory activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.45 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 7.00 |
| CHEMBL116201 | — | — | 1 | 6.52 |
| CHEMBL116755 | — | — | 1 | 6.52 |
| CHEMBL114013 | — | — | 1 | 6.40 |
| CHEMBL116078 | — | — | 1 | 6.40 |
| CHEMBL114516 | — | — | 1 | 6.30 |
| CHEMBL113700 | — | — | 1 | 6.30 |
| CHEMBL115813 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL116201 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL116755 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL114013 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL116078 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL114516 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL113700 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL115813 | — | IC50 | = | 680.0 | nM | 6.17 |