Assay Detail
Functional
CHEMBL782874
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Calcium antagonistic activity determined by the inhibitory effect on high-potassium depolarization-induced contracture in isolated rat aorta.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and structure--activity analysis of novel dihydropyridine derivatives to overcome multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.08 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 5.85 |
| CHEMBL330740 | — | — | 1 | 5.06 |
| CHEMBL558149 | — | — | 1 | 4.34 |
| CHEMBL94172 | — | — | 1 | - |
| CHEMBL329615 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1484 | NICARDIPINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL330740 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL558149 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL94172 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL329615 | — | IC50 | = | 115000.0 | nM | - |