Assay Detail
Functional
CHEMBL782875
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Calcium antagonistic activity was evaluated by in vitro inhibition of [3H]nitrendipine binding on rat cerebral cortex
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
New 1,4-dihydropyridine derivatives combining calcium antagonism and alpha-adrenolytic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.76 | 10.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 10.59 |
| CHEMBL540511 | — | — | 1 | 10.22 |
| CHEMBL2093965 | — | — | 1 | 9.00 |
| CHEMBL542814 | — | — | 1 | 8.47 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1484 | NICARDIPINE | IC50 | = | 0.026 | nM | 10.59 |
| CHEMBL540511 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL2093965 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL542814 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL2 | PRAZOSIN | IC50 | = | 3000.0 | nM | 5.52 |