Assay Detail
Functional
CHEMBL782878
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Compound is evaluated for [3H]dopamine uptake inhibition in rat forebrain
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Forebrain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine homologues at dopamine-uptake and phencyclidine- and sigma-binding sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.27 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279556 | — | — | 1 | 8.05 |
| CHEMBL18618 | — | — | 1 | 7.96 |
| CHEMBL280329 | — | — | 1 | 7.72 |
| CHEMBL273326 | — | — | 1 | 7.62 |
| CHEMBL279873 | — | — | 1 | 7.57 |
| CHEMBL17945 | — | — | 1 | 7.37 |
| CHEMBL428529 | — | — | 1 | 7.26 |
| CHEMBL18556 | — | — | 1 | 7.11 |
| CHEMBL18025 | — | — | 1 | 6.88 |
| CHEMBL18502 | — | — | 1 | 6.83 |
| CHEMBL18190 | — | — | 1 | 6.60 |
| CHEMBL18811 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279556 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL18618 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL280329 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL273326 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL279873 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL17945 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL428529 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL18556 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL18025 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL18502 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL18190 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL18811 | — | IC50 | = | 550.0 | nM | 6.26 |