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Assay Detail

CHEMBL783267

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Functional
Inhibition of dopamine uptake in rat synaptosomal fraction
ChEMBL ↗
71
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Sodium-dependent dopamine transporter (CHEMBL338) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

3-Phenyl-1-indanamines. Potential antidepressant activity and potent inhibition of dopamine, norepinephrine, and serotonin uptake.
Bøgesø KP, Christensen AV, Hyttel J, Liljefors T.
J Med Chem (1985) 28 : 1817 -1828
PubMed 2999402 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 71 7.22 9.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL544971 — — 2 9.92
CHEMBL296602 INDATRALINE 2.0 2 9.77
CHEMBL301514 — — 2 9.28
CHEMBL544266 — — 2 9.00
CHEMBL545201 — — 2 8.82
CHEMBL555549 — — 2 8.68
CHEMBL54177 — — 6 8.64
CHEMBL300019 — — 1 8.60
CHEMBL545671 — — 2 8.60
CHEMBL51224 — — 1 8.25
CHEMBL553590 — — 1 8.18
CHEMBL53635 — — 1 8.10
CHEMBL53837 — — 2 8.00
CHEMBL553385 — — 2 7.92
CHEMBL544500 — — 2 7.85
CHEMBL537996 — — 1 7.72
CHEMBL542850 — — 2 7.68
CHEMBL552891 — — 1 7.57
CHEMBL301782 — — 1 7.55
CHEMBL542121 — — 2 7.54
CHEMBL557823 — — 2 7.50
CHEMBL273575 NOMIFENSINE 4.0 1 7.32
CHEMBL543324 — — 2 7.27
CHEMBL300069 — — 2 7.27
CHEMBL544263 — — 2 7.10
CHEMBL542117 — — 2 7.00
CHEMBL554756 — — 1 6.92
CHEMBL50635 — — 2 6.85
CHEMBL543320 — — 2 6.82
CHEMBL553384 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL544971 — IC50 = 0.12 nM 9.92
CHEMBL296602 INDATRALINE IC50 = 0.17 nM 9.77
CHEMBL301514 — IC50 = 0.52 nM 9.28
CHEMBL544266 — IC50 = 0.99 nM 9.00
CHEMBL545201 — IC50 = 1.5 nM 8.82
CHEMBL555549 — IC50 = 2.1 nM 8.68
CHEMBL54177 — IC50 = 2.3 nM 8.64
CHEMBL300019 — IC50 = 2.5 nM 8.60
CHEMBL545671 — IC50 = 2.5 nM 8.60
CHEMBL301514 — IC50 = 4.1 nM 8.39
CHEMBL54177 — IC50 = 4.4 nM 8.36
CHEMBL544971 — IC50 = 5.0 nM 8.30
CHEMBL51224 — IC50 = 5.6 nM 8.25
CHEMBL553590 — IC50 = 6.6 nM 8.18
CHEMBL53635 — IC50 = 7.9 nM 8.10
CHEMBL296602 INDATRALINE IC50 = 8.6 nM 8.07
CHEMBL53837 — IC50 = 10.0 nM 8.00
CHEMBL54177 — IC50 = 10.0 nM 8.00
CHEMBL54177 — IC50 = 11.0 nM 7.96
CHEMBL553385 — IC50 = 12.0 nM 7.92
CHEMBL544500 — IC50 = 14.0 nM 7.85
CHEMBL53837 — IC50 = 15.0 nM 7.82
CHEMBL537996 — IC50 = 19.0 nM 7.72
CHEMBL544266 — IC50 = 20.0 nM 7.70
CHEMBL542850 — IC50 = 21.0 nM 7.68
CHEMBL552891 — IC50 = 27.0 nM 7.57
CHEMBL301782 — IC50 = 28.0 nM 7.55
CHEMBL542121 — IC50 = 29.0 nM 7.54
CHEMBL553385 — IC50 = 31.0 nM 7.51
CHEMBL557823 — IC50 = 32.0 nM 7.50
CHEMBL273575 NOMIFENSINE IC50 = 48.0 nM 7.32
CHEMBL543324 — IC50 = 54.0 nM 7.27
CHEMBL300069 — IC50 = 54.0 nM 7.27
CHEMBL545201 — IC50 = 62.0 nM 7.21
CHEMBL545671 — IC50 = 67.0 nM 7.17
CHEMBL543324 — IC50 = 71.0 nM 7.15
CHEMBL544263 — IC50 = 79.0 nM 7.10
CHEMBL300069 — IC50 = 83.0 nM 7.08
CHEMBL542117 — IC50 = 100.0 nM 7.00
CHEMBL555549 — IC50 = 120.0 nM 6.92
CHEMBL554756 — IC50 = 120.0 nM 6.92
CHEMBL50635 — IC50 = 140.0 nM 6.85
CHEMBL543320 — IC50 = 150.0 nM 6.82
CHEMBL542850 — IC50 = 150.0 nM 6.82
CHEMBL553384 — IC50 = 160.0 nM 6.80
CHEMBL543320 — IC50 = 180.0 nM 6.75
CHEMBL52904 — IC50 = 180.0 nM 6.75
CHEMBL50635 — IC50 = 190.0 nM 6.72
CHEMBL544500 — IC50 = 220.0 nM 6.66
CHEMBL552808 — IC50 = 240.0 nM 6.62