Assay Detail
Functional
CHEMBL783343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of uptake of noradrenaline in rat brain hypothalamus
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3-(4-Piperidinylalkyl)indoles, selective inhibitors of neuronal 5-hydroxytryptamine uptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.78 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1159861 | — | — | 1 | 6.40 |
| CHEMBL24042 | — | — | 1 | 6.30 |
| CHEMBL25416 | — | — | 1 | 6.22 |
| CHEMBL1159865 | — | — | 1 | 6.22 |
| CHEMBL25428 | — | — | 1 | 6.19 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 6.16 |
| CHEMBL278080 | — | — | 1 | 6.00 |
| CHEMBL1159866 | — | — | 1 | 6.00 |
| CHEMBL543980 | — | — | 1 | 5.89 |
| CHEMBL429771 | — | — | 1 | 5.82 |
| CHEMBL24783 | — | — | 1 | 5.82 |
| CHEMBL276520 | INDALPINE | 4.0 | 1 | 5.80 |
| CHEMBL1159870 | — | — | 1 | 5.75 |
| CHEMBL24731 | — | — | 1 | 5.52 |
| CHEMBL557413 | — | — | 1 | 5.30 |
| CHEMBL278816 | — | — | 1 | 5.19 |
| CHEMBL24075 | — | — | 1 | 5.05 |
| CHEMBL284004 | — | — | 1 | 4.40 |
| CHEMBL544216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1159861 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL24042 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL25416 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1159865 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL25428 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL278080 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1159866 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL543980 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL429771 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL24783 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL276520 | INDALPINE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1159870 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL24731 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL557413 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL278816 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL24075 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL284004 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL544216 | — | IC50 | > | 10000.0 | nM | - |