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Assay Detail

CHEMBL783491

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was evaluated for inhibitory activity against bone resorption in avian osteoclast
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Intermediate

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

17-hydroxywortmannin: A potent inhibitor of bone resorption and phosphatidylinositol-3-kinase
Dodge JA, Bryant HU, Kim J, Matter WF, Norman BH, Srinivasan U, Vlahos CJ, Sato M
Bioorg Med Chem Lett (1995) 5 : 1713 -1718
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 6.55 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL273832 1 8.00
CHEMBL428496 WORTMANNIN 1 7.01
CHEMBL870 ALENDRONIC ACID 4.0 1 7.00
CHEMBL48095 1 6.99
CHEMBL13513 1 6.30
CHEMBL871 ETIDRONIC ACID 4.0 1 4.00
CHEMBL275536 1 -
CHEMBL295740 1 -
CHEMBL13512 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL273832 IC50 = 10.0 nM 8.00
CHEMBL428496 WORTMANNIN IC50 = 98.0 nM 7.01
CHEMBL870 ALENDRONIC ACID IC50 = 100.0 nM 7.00
CHEMBL48095 IC50 = 103.0 nM 6.99
CHEMBL13513 IC50 = 506.0 nM 6.30
CHEMBL871 ETIDRONIC ACID IC50 = 100000.0 nM 4.00
CHEMBL275536 IC50 > 1000.0 nM -
CHEMBL295740 IC50 > 1000.0 nM -
CHEMBL13512 IC50 > 1000.0 nM -