Assay Detail
Functional
CHEMBL783509
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Inhibitory concentration was evaluated against the vasoconstriction induced by NPY in the rat femoral artery ring
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Femoral artery |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Neuropeptide Y (NPY) functional group mimetics: design, synthesis, and characterization as NPY receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.43 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19060 | BENEXTRAMINE | — | 1 | 7.37 |
| CHEMBL290671 | — | — | 1 | 6.38 |
| CHEMBL35694 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19060 | BENEXTRAMINE | IC50 | = | 43.1 | nM | 7.37 |
| CHEMBL290671 | — | IC50 | = | 414.0 | nM | 6.38 |
| CHEMBL35694 | — | IC50 | = | 2860.0 | nM | 5.54 |