Assay Detail
Functional
CHEMBL783620
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Ability to inhibit the release of extravasated dye in the rat peritoneal fluids by 50%
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
N-benzylpiperazino derivatives of 3-nitro-4-hydroxycoumarin with H1 antihistamine and mast cell stabilizing properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.84 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32097 | — | — | 1 | 5.70 |
| CHEMBL74 | CROMOLYN SODIUM | 4.0 | 1 | 5.24 |
| CHEMBL35376 | — | — | 1 | 5.24 |
| CHEMBL534 | KETOTIFEN | 4.0 | 1 | 5.04 |
| CHEMBL32953 | — | — | 1 | 4.89 |
| CHEMBL286017 | — | — | 1 | 4.80 |
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 4.54 |
| CHEMBL36517 | — | — | 1 | 4.08 |
| CHEMBL286094 | — | — | 1 | 4.00 |
| CHEMBL264756 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32097 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL74 | CROMOLYN SODIUM | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL35376 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL534 | KETOTIFEN | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL32953 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL286017 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL511 | PYRILAMINE | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL36517 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL286094 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL264756 | — | IC50 | > | 200000.0 | nM | - |