Assay Detail
Functional
CHEMBL783651
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against uptake of [3H]NE into chopped cerebral cortical tissue from rat brain
10
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pronounced pharmacological differences arising from minor structural changes in conformationally defined amphetamine analogues. Comparative evaluation of endo- and exo-2-amino- and endo- and exo-2-(methylamino)benzobicyclo[2.2.1]heptene and -benzobicylco[2.2.2]octene analogues. Conformationally defined adrenergic agents. 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.52 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | 4.0 | 1 | 6.70 |
| CHEMBL19393 | LEVAMFETAMINE | 4.0 | 1 | 6.30 |
| CHEMBL157518 | — | — | 2 | 6.10 |
| CHEMBL157748 | — | — | 2 | 6.10 |
| CHEMBL49263 | — | — | 1 | 5.96 |
| CHEMBL154758 | — | — | 2 | 5.75 |
| CHEMBL301289 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL612 | DEXTROAMPHETAMINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL19393 | LEVAMFETAMINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL157748 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL157518 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL49263 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL154758 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL157518 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL157748 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL301289 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL154758 | — | IC50 | = | 369000.0 | nM | - |