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Assay Detail

CHEMBL783652

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory concentration of compound against 45 [Ca2+] influx in neonatal rat cultured spinal sensory neurons
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 1 — Organism
Curated By Expert

Target

Rattus norvegicus (CHEMBL376)
Type ORGANISM
Organism Rattus norvegicus

Publication

Chain-branched 1,3-dibenzylthioureas as vanilloid receptor 1 antagonists.
Ryu CH, Jang MJ, Jung JW, Park JH, Choi HY, Suh YG, Oh U, Park HG, Lee J, Koh HJ, Mo JH, Joo YH, Park YH, Kim HD.
Bioorg Med Chem Lett (2004) 14 : 1751 -1755
PubMed 15026064 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.93 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL412885 1 7.30
CHEMBL51077 1 7.30
CHEMBL228451 1 6.96
CHEMBL288760 1 6.82
CHEMBL299369 1 6.44
CHEMBL48902 1 6.40
CHEMBL418088 1 6.24
CHEMBL391997 CAPSAZEPINE 1 6.22
CHEMBL433276 1 5.83
CHEMBL48181 1 5.83
CHEMBL45716 1 5.49
CHEMBL48301 1 5.48
CHEMBL49428 1 5.46
CHEMBL49816 1 5.44
CHEMBL48953 1 5.30
CHEMBL50707 1 4.83
CHEMBL50816 1 4.78
CHEMBL49673 1 4.59

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL412885 IC50 = 50.0 nM 7.30
CHEMBL51077 IC50 = 50.0 nM 7.30
CHEMBL228451 IC50 = 110.0 nM 6.96
CHEMBL288760 IC50 = 150.0 nM 6.82
CHEMBL299369 IC50 = 360.0 nM 6.44
CHEMBL48902 IC50 = 400.0 nM 6.40
CHEMBL418088 IC50 = 580.0 nM 6.24
CHEMBL391997 CAPSAZEPINE IC50 = 600.0 nM 6.22
CHEMBL433276 IC50 = 1470.0 nM 5.83
CHEMBL48181 IC50 = 1490.0 nM 5.83
CHEMBL45716 IC50 = 3240.0 nM 5.49
CHEMBL48301 IC50 = 3300.0 nM 5.48
CHEMBL49428 IC50 = 3490.0 nM 5.46
CHEMBL49816 IC50 = 3600.0 nM 5.44
CHEMBL48953 IC50 = 4960.0 nM 5.30
CHEMBL50707 IC50 = 14700.0 nM 4.83
CHEMBL50816 IC50 = 16700.0 nM 4.78
CHEMBL49673 IC50 = 25500.0 nM 4.59