Assay Detail
Functional
CHEMBL783653
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Inhibition of [Ca2+] uptake in dorsal root ganglion (DRG) neurons from neonatal Sprague-Dawley rat
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Dorsal root ganglion |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.31 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388824 | — | — | 1 | 7.43 |
| CHEMBL228451 | — | — | 1 | 6.96 |
| CHEMBL391997 | CAPSAZEPINE | — | 1 | 6.23 |
| CHEMBL136158 | — | — | 1 | 4.61 |
| CHEMBL137697 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388824 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL228451 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL391997 | CAPSAZEPINE | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL136158 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL137697 | — | IC50 | > | 30000.0 | nM | - |