Assay Detail
Functional
CHEMBL783692
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[3H]5-HT reuptake inhibition in Rat brain synaptosomes.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activity: a new approach toward efficient antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.77 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15663 | — | — | 1 | 9.82 |
| CHEMBL276520 | INDALPINE | 4.0 | 1 | 9.00 |
| CHEMBL15657 | — | — | 1 | 7.96 |
| CHEMBL280089 | — | — | 1 | 7.70 |
| CHEMBL275880 | — | — | 1 | 7.35 |
| CHEMBL275814 | — | — | 1 | 7.26 |
| CHEMBL416899 | — | — | 1 | 7.24 |
| CHEMBL15988 | — | — | 1 | 7.22 |
| CHEMBL278747 | — | — | 1 | 7.22 |
| CHEMBL275628 | — | — | 1 | 6.89 |
| CHEMBL275400 | — | — | 1 | - |
| CHEMBL277147 | — | — | 1 | - |
| CHEMBL15383 | — | — | 1 | - |
| CHEMBL274725 | — | — | 1 | - |
| CHEMBL15958 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15663 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL276520 | INDALPINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL15657 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL280089 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL275880 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL275814 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL416899 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL15988 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL278747 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL275628 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL275400 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL277147 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL15383 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL274725 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL15958 | — | IC50 | > | 100.0 | nM | - |