Assay Detail
Functional
CHEMBL783699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]norepinephrine uptake in rat brain synaptosomes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Conformational analysis and structural comparisons of (1R,3S)-(+)- and (1S,3R)-(-)-tefludazine, (S)-(+)- and (R)-(-)-octoclothepin, and (+)-dexclamol in relation to dopamine receptor antagonism and amine-uptake inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.01 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64249 | CLOROTEPINE | 2.0 | 1 | 9.19 |
| CHEMBL105013 | — | — | 1 | 6.14 |
| CHEMBL6066837 | (-)-BUTACLAMOL | — | 1 | 5.13 |
| CHEMBL95636 | TEFLUDAZINE | 2.0 | 1 | 4.82 |
| CHEMBL1255588 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64249 | CLOROTEPINE | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL105013 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL6066837 | (-)-BUTACLAMOL | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL95636 | TEFLUDAZINE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1255588 | — | IC50 | = | 17000.0 | nM | 4.77 |