Assay Detail
Functional
CHEMBL783701
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Inhibition of amylase release stimulated by CCK-8 (0.1 nM) in dispersed rat pancreatic acini
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.83 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113718 | IQM-95333 | — | 1 | 9.19 |
| CHEMBL3350855 | — | — | 1 | 8.37 |
| CHEMBL3350849 | — | — | 1 | 7.64 |
| CHEMBL3350858 | — | — | 1 | 7.48 |
| CHEMBL3350853 | — | — | 1 | 7.21 |
| CHEMBL116127 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113718 | IQM-95333 | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL3350855 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3350849 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3350858 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3350853 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL116127 | — | IC50 | = | 77.0 | nM | 7.11 |