Assay Detail
Functional
CHEMBL783705
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of galactitol accumulation in rat RBC incubated in presence of 50 mM glucose
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Syntheses of tolrestat analogues containing additional substituents in the ring and their evaluation as aldose reductase inhibitors. Identification of potent, orally active 2-fluoro derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.82 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.82 |
| CHEMBL84152 | — | — | 1 | 7.72 |
| CHEMBL84767 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL84152 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL84767 | — | IC50 | = | 12000.0 | nM | 4.92 |