Assay Detail
Functional
CHEMBL784009
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Compound was evaluated for the inhibition of glutamate-stimulated calcium influx (GSCI)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.63 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 7.27 |
| CHEMBL1795070 | — | — | 1 | 7.00 |
| CHEMBL157931 | — | — | 1 | 6.92 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 6.70 |
| CHEMBL158523 | — | — | 1 | 6.29 |
| CHEMBL158675 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1795070 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL157931 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL275528 | PHENCYCLIDINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL158523 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL158675 | — | IC50 | = | 2550.0 | nM | 5.59 |