Assay Detail
Functional
CHEMBL784013
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated in the rat brain synaptosomal preparations for the inhibition of K+ -evoked glutamate release through block of voltage-gated [Ca2+] -channels
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and characterization of N-(acenaphth-5-yl)-N'-(4-methoxynaphth-1-yl)guanidine as a glutamate release inhibitor and potential anti-ischemic agent
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.16 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28854 | SIPATRIGINE | 2.0 | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28854 | SIPATRIGINE | IC50 | = | 7000.0 | nM | 5.16 |