Assay Detail
Functional
CHEMBL784014
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In vitro inhibition of LTB4 synthesis in rat whole blood.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.11 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423835 | ZM-211965 | — | 1 | 6.52 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423835 | ZM-211965 | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL93 | ZILEUTON | IC50 | = | 2000.0 | nM | 5.70 |