Assay Detail
Functional
CHEMBL784018
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Compound was evaluated in vitro, for the ability to inhibit [3H]- dopamine uptake into synaptosomes (prepared from rat striatal tissues).
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 3-carbamoylecgonine methyl ester analogues as inhibitors of cocaine binding and dopamine uptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.52 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159325 | — | — | 1 | 6.75 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 6.67 |
| CHEMBL163614 | — | — | 1 | 5.24 |
| CHEMBL350155 | — | — | 1 | 4.64 |
| CHEMBL164409 | — | — | 1 | 4.28 |
| CHEMBL348799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159325 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL370805 | COCAINE | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL163614 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL350155 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL164409 | — | IC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL348799 | — | IC50 | > | 100000.0 | nM | - |