Assay Detail
Functional
CHEMBL784059
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Evaluated for the stimulation of synaptosomal release of norepinephrine (release constant)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
In vivo and in vitro studies on the neurotoxic potential of 6-hydroxydopamine analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 4.52 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132149 | — | — | 1 | 4.68 |
| CHEMBL131384 | — | — | 1 | 4.64 |
| CHEMBL130653 | — | — | 1 | 4.47 |
| CHEMBL131383 | — | — | 1 | 4.29 |
| CHEMBL132012 | — | — | 1 | - |
| CHEMBL130521 | — | — | 1 | - |
| CHEMBL337702 | OXIDOPAMINE | 2.0 | 1 | - |
| CHEMBL28225 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132149 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL131384 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL130653 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL131383 | — | EC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL132012 | — | EC50 | = | 672000.0 | nM | - |
| CHEMBL130521 | — | EC50 | = | 212000.0 | nM | - |
| CHEMBL337702 | OXIDOPAMINE | EC50 | = | 828000.0 | nM | - |
| CHEMBL28225 | — | EC50 | = | 317000.0 | nM | - |