Assay Detail
Functional
CHEMBL784063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
G protein activation was measured by stimulation of [35S]GTP gamma-S binding to rat adipocyte membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrazole derivatives as partial agonists for the nicotinic acid receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 4.86 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL573 | NIACIN | 4.0 | 1 | 5.77 |
| CHEMBL428730 | — | — | 1 | 5.38 |
| CHEMBL237788 | — | — | 1 | 5.21 |
| CHEMBL128604 | — | — | 1 | 5.19 |
| CHEMBL238002 | — | — | 1 | 4.86 |
| CHEMBL128679 | — | — | 1 | 4.80 |
| CHEMBL394441 | — | — | 1 | 4.33 |
| CHEMBL247317 | — | — | 1 | 4.15 |
| CHEMBL338405 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL573 | NIACIN | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL428730 | — | EC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL237788 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL128604 | — | EC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL238002 | — | EC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL128679 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL394441 | — | EC50 | = | 46600.0 | nM | 4.33 |
| CHEMBL247317 | — | EC50 | = | 70700.0 | nM | 4.15 |
| CHEMBL338405 | — | EC50 | = | 85100.0 | nM | 4.07 |